The activating and inhibitory receptors as pro-inflammatory/pro-resolutory targets for allergic inflammation
نویسندگان
چکیده
منابع مشابه
P 107: P2x7 Receptors: as a Novel Targets for the Treatment of Neuroinflammation
P2x7 receptors are Purineric receptors that are extracellular ATP-gated ion channel. These receptors require high dose or prolonged exposure to ATP for initial activation. The Activation of these receptors facilitates the formation of inflammasome which activates caspase 1. The P20 and P10 subunits of caspase 1 form active enzyme that then releases active interleukin (IL)-1 β and IL-18, tu...
متن کاملPeroxisome proliferator-activated receptors as therapeutic targets in inflammation.
For decades, advances in endocrinology were characterized by a process in which hormones were first identified based upon their physiologic roles and then purified, often from vast quantities of biologic material. This purified material was then used to identify the receptors through which the hormone signaled. In this classic progression, science moved from physiology to cellular signaling. Mo...
متن کاملThe role of histamine H4 receptors as a potential targets in allergic rhinitis and asthma
Histamine—the main product of mast cells plays critical role in the pathogenetic pathways of both allergic rhinitis and asthma. The novel concept of the unique airway diseases its only supported by the similarities within pathogenetic process. Antagonists of H1 and H2 receptors are quite effective in allergic rhinitis, but not effective enough in asthma. In an era of corticosteroids, leucotrien...
متن کاملInhibitory receptors on myeloid cells: new targets for therapy?
Immune regulation of cellular activation is a tightly regulated process dictated by a balance of activation and inhibitory signals. Although initially described and characterized on natural killer cells, it has become increasingly apparent that inhibitory receptors are expressed and functional on myeloid cells. These receptors can override signals elicited by activation pathways including cytok...
متن کاملthe search for the self in becketts theatre: waiting for godot and endgame
this thesis is based upon the works of samuel beckett. one of the greatest writers of contemporary literature. here, i have tried to focus on one of the main themes in becketts works: the search for the real "me" or the real self, which is not only a problem to be solved for beckett man but also for each of us. i have tried to show becketts techniques in approaching this unattainable goal, base...
15 صفحه اولذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings for Annual Meeting of The Japanese Pharmacological Society
سال: 2018
ISSN: 2435-4953
DOI: 10.1254/jpssuppl.wcp2018.0_sy79-1